Nothing much here... these are two endogenous opiates (that means they are found in the brain naturally and normally)... the first one is 30 times more potent than morphine... the second has too low of a seizure theshold to be useful...<font face="Verdana, Arial" size="2">Originally posted by emiwee:
Pharmacological characterization of morphine-6-sulfate and codeine-6-sulfate.
Zuckerman A; Bolan E; de Paulis T; Schmidt D; Spector S; Pasternak GW</font>
"Specific immunotoxicological effects were observed at doses where no effects were seen in routine toxicological evaluation, suggesting that the immune system is sensitive to opiates."<font face="Verdana, Arial" size="2">Immunotoxicological screening of morphine and methadone in an extended 28 day study in rats.
van der Laan JW; Krajnc EI; Krajnc-Franken MA; van Loveren H</font>
Sorry, nothing about neurotoxicitt
<font face="Verdana, Arial" size="2">Functional neurotoxicity of drugs of abuse.
Basically bullshit... bad theory based in some wacked out crap... "this may represent a subtle mechanism through which drugs of abuse may induce behavioral toxicity even in the absence of nerve cell loss"...
Yeah, okay, buddy, whatever you say...
Here, check what they REALLY died of...<font face="Verdana, Arial" size="2">Methadone toxicity causing death in ten subjects starting on a methadone maintenance program.
Drummer OH Opeskin K; Syrjanen M; Cordner SM</font>
"Complete toxicological analysis showed that six subjects had additional drugs present including two with alcohol, two with benzodiazepines and morphine, and one with benzodiazepines alone. Pathological examination revealed the presence of chronic persistent hepatitis in all subjects and bronchopneumonia in five."