One-off events are all well and good, but they require advance planning, and are usually 2-3x the price. Sometimes it's nice to just be able to go to Venue ABC and know that they'll be playing house/techno/whatever.
less weeklies, but i know there's thursday night d&b @ Thymless and Sunday Night d&b at Tota. (i have no idea if they are usually bumping or dead - but i passed by thymless about a month ago and it was absolutely dead - could have been an off night though....)
I'm way, WAY out of the scene now, but there's always stuff going on at Round in Kensington every week. Also, there's the Sunday Social parties, but you need to take out a small bank loan to go to all those parties these days.